Markosyan was born in Yerevan in 1937. In 1961 he graduated from the faculty of mechanics and mathematics of Yerevan State University. After receiving his PhD in 1968, he started teaching at Yerevan Polytechnic Institute and Yerevan State University. Markosyan is one of the recognized experts in the field of graph theory and automatic topology design of large integrated circuits (ICs). The methods and problems he proposed in the field of graph theory were developed by famous mathematicians from Canada, Italy and Brazil. A group of mathematicians from the "Artemis" laboratory of Grenoble University were engaged in the study of critically imperfect graphs defined by Professor Markosyan. They named the "symmetric theorem" obtained by Markosyan and his students “Armenian". One of the key areas of Markosyan's scientific research was also the automatic design of the topology of large integrated circuits. He was one of the first to propose the "method of intervals" in the 1970s, which later became one of the main methods of physical design of large integrated circuits. Markosyan was ahead of foreign specialists in the development of several algorithms. Years later they repeated the results obtained by Markosyan. Markosyan carried out practical works as well. Under his leadership and participation, automatic design systems were developed and implemented in various institutions, both in Armenia and abroad. At the end of the 1990s, the company “ARSET" of automatic design of integrated circuits was established in Armenia, one of the founders of which was Professor Markosyan. Later, that company became part of Synopsis Armenia. It was also due to Markosyan's efforts that the field of automatic design of integrated circuits is developed in Armenia and accounts for 5% of the world's output. Professor Markosyan is the author of one monograph and more than 60 published works, some of which were published in prestigious international journals: